NeuroscienceThe EMBO JournalPeer-reviewed
Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A
Merja Joensuu, Parnayan Syed, Saber H. Saber…·Frédéric A. Meunier
This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.