James A. Rae

This study shows that mural cells are not required for BBB function in developing zebrafish but protect against hemorrhage-induced BBB breakdown in adults.

This study investigates the role of cardiomyocyte caveolae and cavin-1 in myocardial function, revealing sex-dependent effects on ventricular compliance and resilience through mechanisms involving NOS signaling and fibrosis.

The paper shows that lipid droplets store polyunsaturated fatty acids (PUFAs) that are critical for bacterial clearance and inflammation by macrophages.

This paper introduces caveospheres, a modular nanovesicle system for targeted delivery of various cargo, demonstrating efficacy in both in vitro and in vivo applications.

The paper develops a method to express and visualize eukaryotic proteins using cell-free systems and cryo-electron tomography, demonstrating its application to study ASC protein filaments and their interaction with ribosomes.

This paper develops a standardized protocol to assess nanoparticle trans-endothelial trafficking in zebrafish, identifying transport mechanisms for PEG-based nanoparticles.

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

This study identifies specific unsaturated lipids as critical for caveola formation and their disassembly under oxidative stress.

The paper develops nanobodies that bind Cavin1's HR1 domain, revealing structural flexibility and regulated interactions important for caveolae assembly.

This study shows that lipid packing, particularly cholesterol, influences caveolae stability and dynamics in the plasma membrane.

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.