Author

Ailisa Blum

The University of QueenslandORCID 0000-0003-4666-9255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Anmin JiangiD· 2 shared Brett M. CollinsiD· 2 shared Frédéric A. MeunieriD· 2 shared Merja JoensuuiD· 2 shared Rachel S. GormaliD· 2 shared Tristan P. WallisiD· 2 shared Andreas RummeliD· 1 shared Christopher SmalliD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersNeuroscience

Anmin JiangORCID

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2 papers

Recent·Most cited

VAMP2/Munc18-1 domain 3a interaction controls the nanoscale reorganization underpinning vesicular priming

Anmin Jiang, Rachel S. Gormal, Ravikiran Kasula, Ailisa Blum, Mercè Salla‐Martret, Ye Jin Chai, Tristan P. Wallis, Julie Z. Brouillet, Pranesh Padmanabhan, Saroja K. Weeratunga, Emma K. Livingstone, Mahdie Mollazade, Merja Joensuu, Ramón Martínez‐Mármol, Brett M. Collins, Frédéric A. Meunier

The paper identifies key residues in Munc18-1 domain 3a that regulate the interaction with VAMP2, controlling nanoscale reorganization necessary for vesicular priming and secretion.

bioRxiv · Sep 10, 2023 · PreprintNeuroscience

Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A

Merja Joensuu, Parnayan Syed, Saber H. Saber, Vanessa Lanoue, Tristan P. Wallis, James A. Rae, Ailisa Blum, Rachel S. Gormal, Christopher Small, Shanley F. Longfield, Anmin Jiang, Stefan Mahrhold, Nadja Krez, Michael Alan Cousin, Ruby Cooper‐White, , Frédéric A. Meunier

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

The EMBO Journal · May 25, 2023Peer-reviewedNeuroscience