Saverio Brogna

This study shows that nonsense mutations can increase mRNA levels in S. pombe, challenging the conventional understanding of NMD and its impact on transcript abundance.

This study shows UPF1 localizes to mitochondria in Drosophila and affects mitochondrial gene expression and function independently of its role in NMD.

This paper reports genome-wide ChIP data showing Upf1 associates with active genes in S. pombe, correlating with Pol II transcription and mRNA levels, and reveals transcriptional defects in Upf1-deficient cells.

The paper shows that an intron near a PTC enhances NMD in S. cerevisiae, independent of EJC and splicing direction.