Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia
Funda Orhan, Susmita Malwade, Neda Khanlarkhani, Asimenia Gkoga, Oscar Jungholm, Marja Koskuvi, Šárka Lehtonen, Lilly Schwieler, Kent E. Jardemark, Jari Tiihonen, Jari Koıstınaho, Sophie Erhardt, Göran Engberg, Samudyata Samudyata, Carl M. Sellgren
This study shows that kynurenic acid promotes microglia-mediated synaptic pruning in schizophrenia by reducing neuronal activity and linking genetic risk variants to KYNA production.
bioRxiv · Oct 19, 2023 · PreprintNeuroscience