Aurore Thomazeau

Distinct NMDA Receptor Pools Determine Diverse Forms of Cortical Plasticity

The paper investigates the role of presynaptic and postsynaptic NMDA receptors in synaptic plasticity and circuit structure in mouse visual cortex.

Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling

This study shows that tLTD in neocortical layer-5 pyramidal cell synapses depends on non-ionotropic preNMDAR signaling via JNK2/STX1a, challenging the traditional view of NMDARs as ionotropic coincidence detectors.

Non-ionotropic signaling through the NMDA receptor GluN2B carboxy terminal domain drives morphological plasticity of dendritic spines and reverses fragile X phenotypes in mouse hippocampus

Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndrome

This study investigates synaptic deficits in the prefrontal cortex of Ts65Dn mice, a model for Down syndrome, and compares them to mBACtgDyrk1a mice, revealing differences in synaptic plasticity and intrinsic neuronal properties.

Electrophysiological signatures of visual recognition memory across all layers of mouse V1

The paper investigates electrophysiological changes in mouse V1 during visual recognition memory, showing that NMDAR in L6 principal neurons are critical for SRP and revealing layer-specific responses to familiar stimuli.

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.