Author

Jean-François Darrigrand

King's College LondonORCID 0000-0002-5624-7585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Francesca M. SpagnoliiD· 4 shared Anna SalowkaiD· 3 shared David WillnowiD· 2 shared Abigail IsaacsoniD· 1 shared Alejo Torres-CanoiD· 1 shared Aleksandra SapalaiD· 1 shared Alessandra VigilanteiD· 1 shared Anat Schonblum· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersDevelopmental Biology

Francesca M. SpagnoliORCID

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Author profile →

5 papers

Recent·Most cited

Spatially organized cellular communities shape functional tissue architecture in the pancreas

Alejo Torres-Cano, Jean-François Darrigrand, Gabriel Emilio Herrera-Oropeza, Georgina Goss, David Willnow, Anna Salowka, Siwanart Ma, Debashish Chitnis, M. Rouault, Alessandra Vigilante, Francesca M. Spagnoli

This study maps pancreatic cell populations across space and time in mice, revealing spatially organized niches and their functional roles in development and adult homeostasis.

Science Advances · Nov 12, 2025Peer-reviewedDevelopmental Biology

Generation of human iPSC-derived pancreatic organoids to study pancreas development and disease

Jean-François Darrigrand, Abigail Isaacson, Francesca M. Spagnoli

This paper develops a protocol to generate human iPSC-derived pancreatic organoids with proper architecture and patterning, aiming to replace animal models in studying pancreas development and disease.

F1000Research · Jun 10, 2025Peer-reviewedDevelopmental Biology

Acinar-ductal cell rearrangement drives pancreas branching morphogenesis in an IGF/PI3K-dependent manner

Jean-François Darrigrand, Anna Salowka, Francesca M. Spagnoli

The paper identifies acinar-ductal cell rearrangements driven by the IGF/PI3K pathway as a mechanism for pancreas branching morphogenesis while preserving acinar-ductal unit integrity.

bioRxiv · Jan 26, 2023 · PreprintDevelopmental Biology

Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions

Laura Glorieux, Aleksandra Sapala, David Willnow, Manon Moulis, Anna Salowka, Jean-François Darrigrand, Shlomit Edri, Anat Schonblum, Lina Sakhneny, Laura Schaumann, Harold Fernando Gómez, Christine Lang, Lisa Conrad, Fabien Guillemot, Shulamit Levenberg, , Francesca M. Spagnoli

The paper develops a 3D atlas of the embryonic pancreas to analyze cell interactions and spatial organization in mouse embryos.

Development · Jan 17, 2022Peer-reviewedDevelopmental Biology

Transcriptional control of cardiac neural crest cells condensation and outflow tract septation by the Smad1/5/8 inhibitor Dullard

Jean-François Darrigrand, Mariana Valente, Pauline Martinez, Glenda Comai, Maxime Petit, Ryuichi Nishinakamura, Daniel S. Osório, Vanessa Ribes, Bruno Cadot

The paper investigates how BMP signaling, through the Smad1/5/8 inhibitor Dullard, regulates cardiac neural crest cell behavior and outflow tract septation in vertebrates.

bioRxiv · Aug 8, 2019 · PreprintDevelopmental Biology