A human-specific regulatory mechanism revealed in a preimplantation model
Raquel Fueyo, Sicong Wang, Olivia J Crocker…·Joanna Wysocka
The paper investigates the role of HERVK LTR5Hs elements in human preimplantation development, showing their cis-regulatory impact on the epiblast transcriptome and their essential role in blastoid formation through ZNF729 activation.