Author

Isabella M. Valentino

Cold Spring Harbor LaboratoryORCID 0000-0001-7128-1469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Andrew M. Lehman· 1 shared Brett Pryor· 1 shared Carlos A. CastañedaiD· 1 shared Christopher M. HammelliD· 1 shared Daniel Adam KrautiD· 1 shared David F. RitteriD· 1 shared Erica L. Mallon· 1 shared Erin O. Mulvey· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Andrew M. Lehman

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2 papers

Recent·Most cited

Developmental BiologybioRxivPreprintJan 23, 2026

A developmental timer coordinates organism-wide microRNA transcription

Peipei Wu, Jing Wang, Brett Pryor…·Christopher M. Hammell

The paper identifies a developmental timer in C. elegans that coordinates microRNA transcription across tissues through a feedback loop between MYRF-1 and LIN-42.

DOI 10.64898/2026.01.21.700890

C. elegansDNA methylation

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedAug 9, 2024

Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate

Isabella M. Valentino, Jeniffer G. Llivicota-Guaman, Thuy Phuong Dao…·Daniel Adam Kraut

This study shows that polyubiquitinated substrates modulate UBQLN2 phase separation in a linkage-dependent manner, affecting proteasome activity and deubiquitination.

24 citations

proteomicsexperimental assay

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