Daniel S. Saxton

This study identifies SNIPE as a bacterial membrane-bound nuclease that directly cleaves phage DNA during genome injection, providing a novel mechanism for distinguishing self from non-self.

The paper develops a mathematical model showing bidirectional feedback between chromatin compaction and histone modifications explains bistability in S. cerevisiae heterochromatin.

This study identifies a novel SIR2 allele in yeast that causes heritable intermediate silencing of gene loci, distinct from complete silencing or expression.

The paper investigates whether histone modifications are necessary for heterochromatin inheritance and finds that histone inheritance does not significantly affect silencing stability in yeast.