Christopher R. Doering

This study identifies SNIPE as a bacterial membrane-bound nuclease that directly cleaves phage DNA during genome injection, providing a novel mechanism for distinguishing self from non-self.

The paper identifies a novel anti-viral mechanism where CmdT, an ADP-ribosyltransferase, targets mRNA to block translation and inhibit phage replication.

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.