Jasper Rine

The paper develops a mathematical model showing bidirectional feedback between chromatin compaction and histone modifications explains bistability in S. cerevisiae heterochromatin.

This study investigates Rap1's dual role in gene silencing and activation in yeast, showing its function depends on chromatin context rather than binding-site availability.

The paper distinguishes between recruitment and spread of silent chromatin structures in yeast by using a fusion protein and long-read sequencing to map Sir3-chromatin interactions at single base-pair resolution.

This study identifies a novel SIR2 allele in yeast that causes heritable intermediate silencing of gene loci, distinct from complete silencing or expression.

The paper shows that silencing establishment in yeast requires S-phase progression due to removal of transcription-favoring histone modifications.

The paper creates a proactive map of CBS gene variant function and vitamin B6 response using yeast assays, predicting disease severity and therapy effectiveness.

The paper investigates whether histone modifications are necessary for heterochromatin inheritance and finds that histone inheritance does not significantly affect silencing stability in yeast.

The paper investigates how POL30 alleles affect transcriptional silencing and chromatin assembly in yeast, revealing ploidy-dependent effects on genome stability.

The paper identifies rare coding variants in genes associated with cleft lip with or without cleft palate by sequencing 49 candidate genes in cases and controls, finding higher variant burdens in cases.

The paper identifies a mechanism by which PCNA unloading activity coordinates DNA replication with nucleosome assembly to maintain heterochromatin silencing during S-phase.