Peiwei Chen

This study shows that loss of the piRNA pathway in Drosophila leads to episodic and stochastic transposition bursts, not just increased transposition rates.

The paper identifies a new defense mechanism in Drosophila that enhances the piRNA pathway to control an expanded meiotic driver by increasing the expression of PIWI-clade nucleases.

The paper shows that Drosophila males produce Su(Ste) piRNAs through 5'-to-3' phased biogenesis triggered by maternally deposited piRNAs, and this process is bypassed when mothers are XXY.

This study identifies the genetic mechanisms controlling sex-specific piRNA programs in Drosophila, showing that sex chromosome presence and sexual identity regulate piRNA biogenesis.

The paper shows that the RDC complex regulates piRNA cluster transcription and transposon silencing in Drosophila male germline, with dynamic localization affecting piRNA programs during spermatogenesis.

The paper identifies sex-specific piRNA regulation of transposons and host genes in D. melanogaster male germline, revealing paralog-specific gene silencing.