Yicheng Luo

FlyAnatoView projects Drosophila scRNA-seq data onto anatomical diagrams to restore spatial context and enable exploration of gene expression patterns across tissues.

This study shows that Arp6 and H2Av maintain genomic stability in Drosophila by promoting piRNA pathway gene transcription, which is essential for suppressing transposable elements in the germline.

The paper shows that Rhi recruitment to genomic targets in Drosophila is mediated by a combination of H3K9me3 binding and a piRNA-guided scaffold involving Panx and Kipf.

The paper shows that cytoplasmic inheritance of piRNAs is critical for piRNA biogenesis and that trans-acting piRNAs connect piRNA clusters into a functional network.

The paper identifies a new defense mechanism in Drosophila that enhances the piRNA pathway to control an expanded meiotic driver by increasing the expression of PIWI-clade nucleases.

The paper shows maternally inherited siRNAs trigger de novo formation of piRNA clusters in Drosophila, which then sustain themselves without ongoing siRNA input.

The paper shows that the RDC complex regulates piRNA cluster transcription and transposon silencing in Drosophila male germline, with dynamic localization affecting piRNA programs during spermatogenesis.

The paper shows that the SUMO pathway represses interrupted rDNA units and regulates expression of intact rDNA in Drosophila melanogaster, reducing cell-to-cell heterogeneity.

The paper shows that Su(var)2-10 regulates gene expression in euchromatin and heterochromatin by establishing H3K9me3 and providing negative feedback.

This study shows that SUMO and Su(var)2-10 are required for piRNA-guided chromatin silencing in Drosophila by linking target recognition to histone methyltransferase recruitment.