Author

Ayca Bagci

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Ildar V. GainetdinoviD· 3 shared Phillip D. ZamoreiD· 3 shared Katharine R. CecchiniiD· 2 shared Alexei A. AraviniD· 1 shared Amena ArifiD· 1 shared Cansu ColpaniD· 1 shared Charlotte P. ChoiiD· 1 shared Chiraag Balsara· 1 shared

Activity by Year

2022-2024 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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3 shared papersMolecular Biology

Ildar V. GainetdinovORCID

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3 papers

Recent·Most cited

Mouse Pachytene piRNAs Cleave Hundreds of Transcripts,But Alter the Steady-State Abundance of Only a Minority of Targets

Katharine R. Cecchini, Nandagopal Ajaykumar, Ayca Bagci, Phillip D. Zamore, Ildar V. Gainetdinov

This study shows pachytene piRNAs predominantly cleave hundreds of transcripts but only significantly alter the steady-state abundance of a minority, suggesting their evolutionary retention is driven by a few critical targets.

bioRxiv · Nov 2, 2024 · PreprintMolecular Biology

Drosophila Males Use 5'-to-3' Phased Biogenesis to Make Stellate-silencing piRNAs that Lack Homology to Maternally Deposited piRNA Guides

Zsolt G. Venkei, Ildar V. Gainetdinov, Ayca Bagci, Margaret R. Starostik, Charlotte P. Choi, Jaclyn M. Fingerhut, Peiwei Chen, Chiraag Balsara, Troy W. Whitfield, George W. Bell, Suhua Feng, Steven E. Jacobsen, Alexei A. Aravin, John K. Kim, Phillip D. Zamore, Yukiko M Yamashita

The paper shows that Drosophila males produce Su(Ste) piRNAs through 5'-to-3' phased biogenesis triggered by maternally deposited piRNAs, and this process is bypassed when mothers are XXY.

Nature Cell Biology · Sep 18, 2023Peer-reviewedDevelopmental Biology

Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons

Ildar V. Gainetdinov, Katharine R. Cecchini, Joel Vega‐Badillo, Ayca Bagci, Cansu Colpan, Amena Arif, Pei‐Hsuan Wu, Phillip D. Zamore

This study shows PIWI-clade Argonaute proteins can cleave transposon transcripts with mismatches, making them more effective against mutating transposons than AGO-clade Argonautes.

bioRxiv · Aug 4, 2022 · PreprintMolecular Biology