Author

Li Fan

Chinese Academy of SciencesORCID 0000-0002-6763-0467Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Li Fan3 papers · Air Force Medical University

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alex William HewittiD· 1 shared Alice PébayiD· 1 shared Anna Elizabeth KingiD· 1 shared Anthony L. CookiD· 1 shared Bang Viet BuiiD· 1 shared Daqi DengiD· 1 shared Duo XieiD· 1 shared Guei‐Sheung LiuiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Alex William HewittORCID

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2 papers

Recent·Most cited

Single-crypt evolutionary trajectories of human sporadic and hereditary colorectal precancers

Shanlan Mo, Duo Xie, Hao Zhang, Kun Wang, Juanzhen Tong, Li Fan, Daqi Deng, Jie Yu, Jing Yu, Zan Li, Leo T. O. Lee, Weiwei Zhai, Zhen He, Zheng Hu

This study compares the genomic evolution of sporadic and hereditary colorectal precancers using single-crypt whole-genome sequencing, revealing distinct mutation patterns and evolutionary trajectories.

bioRxiv · Apr 14, 2026 · PreprintCancer Biology

Efficacy and dynamics of self-targeting CRISPR/Cas constructs for gene editing in the retina.

Li Fan, Sandy S. C. Hung, Mohd Khairul Nizam Mohd Khalid, Jiang-Hui Wang, Vicki Chrysostomou, Vickie H. Y. Wong, Vikrant Singh, Kristof Wing, Leilei Tu, James A. Bender, Alice Pébay, Anna Elizabeth King, Anthony L. Cook, Raymond C.B. Wong, Bang Viet Bui, , Guei‐Sheung Liu

This study develops a self-destructing CRISPR/Cas system for retinal gene editing, showing reduced SpCas9 mRNA and improved safety without compromising on-target efficiency.

Human Gene Therapy · Aug 2, 2019Peer-reviewedGenetics