Zachary R. Lanzar

This study shows that excess IL-18 protects against CNS autoimmunity by activating CD8 T-cells to suppress CD4 T-cells involved in autoimmune encephalomyelitis.

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

The paper develops the STORE.2 model to simulate CD8+ T cell proliferation and response to antigen presentation, showing its accuracy in vitro and in vivo.