David A. Christian

The role of integrins in T cell-mediated resistance to Cryptosporidium parvum

This study investigates the role of integrins in T cell trafficking and resistance to Cryptosporidium parvum, finding that integrin L is critical for T cell-mediated control of infection while 4β7 is not essential.

IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

An IL-12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8+ T cell responses

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

The STORE.2 model of the T cell proliferative phase considering c-Myc

The paper develops the STORE.2 model to simulate CD8+ T cell proliferation and response to antigen presentation, showing its accuracy in vitro and in vivo.

The latent stage of Toxoplasma gondii is targeted by the immune response and host protective

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+ T cell responses

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

IL-27 Stablizes Myc-Mediated Transcription In Memory-Fated, Vaccine-Elicited CD8+ T Cells

Subunit vaccines induce CD8+ T cells with memory fate characteristics that maintain proliferative capacity via IL-27 receptor signaling during expansion.