Alexander I. Alexandrov

The paper introduces a single-cell flow cytometry method to assess proteome perturbations in yeast, revealing that aromatic amino acids and oxidative stress jointly contribute to the toxicity of lipophilic nucleoside analogs.

This study investigates the physiological impact of folded-state protein agglomerates in yeast, finding they do not disrupt proteostasis or cell fitness and show minimal effects on cellular processes.

The paper investigates how a standard knockout procedure in yeast affects the expression of neighboring genes at the translational level, revealing significant changes in protein abundance.

The paper maps amyloid cores of 26 [PSI+] prion isolates and identifies two distinct structural classes based on digestion patterns and phenotypic effects.