Claudio Grassi

Recovery after human bone marrow mesenchymal stem cells (hBM-MSCs)-derived extracellular vesicles (EVs) treatment in post-MCAO rats requires handling associated with repeated behavioral testing.

This study shows that handling with behavioral testing is necessary for EVs to improve recovery in post-stroke rats, and a single EV dose enhances this recovery without affecting ischemic damage.

Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

This study identifies biliverdin reductase (BVR) as a bridge between FAK/Pyk2 and Src, showing its role in synaptic signaling and learning/memory deficits in BVR-null mice.

A failure of β-amyloid physiological function due to genetic deletion of α7 nicotinic acetylcholine receptors induces an Alzheimer's disease-like pathology

This study shows that deleting α7 nicotinic acetylcholine receptors in mice leads to Alzheimer's-like pathology through increased amyloid-beta and tau abnormalities.