Author

Chirag Vasavda

Johns Hopkins UniversityORCID 0000-0003-4558-4698Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 3 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Bindu Diana PauliD· 3 shared Ryan S. DhindsaiD· 3 shared Solomon H. SnyderiD· 3 shared Adele M. Snowman· 2 shared Cristina RiccoiD· 2 shared Eugenio BaroneiD· 2 shared Evan R. SemenzaiD· 2 shared Michael D. KornbergiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Bindu Diana PaulORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Metabolite-Based Resistance Mechanism Against Malaria

Ana Leonor Figueiredo, Sharad Rastogi, Susana Ramos, Fátima Nogueira, Katherine A. de Villiers, António G. G. Sousa, Lasse Votborg-Novél, Cäcilie von Wedel, Pinkus Tober‐Lau, Elisa Jentho, Sara Emanuela Pagnotta, Miguel Mesquita, Sílvia Cardoso, Giulia Bortolussi, Andrés Fernando Muro, , Miguel Parreira Soares

The paper identifies unconjugated bilirubin as a protective metabolite against malaria by inhibiting parasite proliferation and hemozoin formation.

Science · Jun 12, 2025Peer-reviewedImmunology

Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S. Dhindsa, Samaneh Saberi, Julia E. Lefler, Priyanka Kothari, Kalyani Chaubey, Cristina Ricco, Adele M. Snowman, Michael C. Ostrowski, Eugenio Barone, Lakshminarayan M. Iyer, , Bindu Diana Paul

This paper identifies a novel non-enzymatic role for BVRA in modulating Nrf2 signaling, revealing its importance in neuroprotection and potential as a therapeutic target for neurodegenerative diseases.

bioRxiv · Jun 4, 2025 · PreprintNeuroscience

Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

Chirag Vasavda, Evan R. Semenza, Jason Liew, Ruchita Kothari, Ryan S. Dhindsa, Shruthi Shanmukha, Anthony L. Lin, Robert A. Tokhunts, Cristina Ricco, Adele M. Snowman, Lauren K. Albacarys, Francesco Pastore, Cristian Ripoli, Claudio Grassi, Eugenio Barone, , Solomon H. Snyder

This study identifies biliverdin reductase (BVR) as a bridge between FAK/Pyk2 and Src, showing its role in synaptic signaling and learning/memory deficits in BVR-null mice.

Science Signaling · May 10, 2022Peer-reviewedNeuroscience

D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain

Evan R. Semenza, Maged M. Harraz, Efrat Abramson, Adarsha P. Malla, Chirag Vasavda, Moataz M. Gadalla, Michael D. Kornberg, Solomon H. Snyder, Robin Roychaudhuri

This study identifies D-cysteine as an endogenous regulator of neural progenitor cell dynamics in the mammalian brain, showing its antiproliferative effects and role in cortical development.

Proceedings of the National Academy of Sciences · Sep 23, 2021Peer-reviewedNeuroscience

Establishing a transcriptome-based drug discovery paradigm for neurodevelopmental disorders

Ryan S. Dhindsa, Anthony William Zoghbi, Daniel K. Krizay, Chirag Vasavda, David B. Goldstein

This paper proposes a transcriptome reversal approach for drug discovery in neurodevelopmental disorders to identify compounds that reverse disease-associated gene-expression signatures.

bioRxiv · May 13, 2020 · PreprintGenomics