Author
Institut PasteurORCID 0000-0003-2950-7035Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Flavio Alvarez, Florence Larrous, Ariel Méchaly…·Célia Caillet‐Saguy
This paper identifies small molecules that inhibit the SARS-CoV-2 E protein interaction with ZO-1 PDZ2 using X-ray crystallography, HTRF screening, and docking simulations, with one compound showing antiviral activity.
Flavio Alvarez, Guilherme Dias de Melo, Florence Larrous…·Célia Caillet‐Saguy
This study shows that the SARS-CoV-2 E protein's PDZ-binding motif enhances virulence by disrupting epithelial barriers and inflammation, but not neuroinvasion.
Guilherme Dias de Melo, Victoire Perraud, Flavio Alvarez…·Hervé Bourhy
The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.