Agnès Thierry

Bacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interactions patterns

The paper investigates the 3D genome structuration and dynamics of bacteriophage PAK_P3 during infection of Pseudomonas aeruginosa, revealing specific interactions between phage and host genomes.

HU promotes higher-order chromosome organisation and influences DNA replication rates in Streptococcus pneumoniae

This study investigates the role of HU in chromosome organization and replication in Streptococcus pneumoniae, showing it promotes long-range interactions and supports replication and segregation.

Z-DNA formation induces the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization

The paper shows that Z-DNA formation promotes totipotent-like state and primes Zscan4-dependent chromatin compartmentalization during early mouse development.

Mechanism of homology search expansion during recombinational DNA break repair

This paper investigates the mechanism of homology search expansion during DNA break repair, revealing how chromatin structure, NPF stiffening, and resection drive genome-wide search.

Chromosome-level genome assembly of the European Green woodpecker Picus viridis

This study presents a chromosome-level genome assembly for the European Green Woodpecker, Picus viridis, using short and long-read sequencing combined with Hi-C scaffolding.

Sister chromatid cohesion halts DNA loop expansion

The paper shows that sister chromatid cohesion inhibits cohesin-mediated DNA loop expansion during G2 phase.

Anchoring of parasitic plasmids to inactive regions of eukaryotic chromosomes through nucleosome signal

The paper identifies how the 2μ plasmid in yeast binds to inactive chromosomal regions through nucleosome signals and RNA Pol II depletion, revealing a stable and rapid tethering mechanism.

Absence of chromosome axis proteins recruitment prevents meiotic recombination chromosome-wide in the budding yeast Lachancea kluyveri

The paper shows that absence of Red1 and Hop1 recruitment prevents meiotic recombination on a chromosome arm containing the sex locus in Lachancea kluyveri, affecting genome evolution and fitness.

Synthetic chromosome fusion: effects on genome structure and function

The paper synthesizes a shorter yeast chromosome and studies its fusion with other chromosomes, revealing new 3D structural interactions and Red1 binding patterns.

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.

Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization

This study shows that bacterial chromosomes can undergo chromatin assembly, activity, looping, and compartmentalization in yeast, driven by their sequence composition.

Chromosome-scale assemblies of Acanthamoeba castellanii genomes provide insights into Legionella pneumophila infection-related chromatin re-organization

The paper presents chromosome-scale genome assemblies of Acanthamoeba castellanii and shows infection-induced chromatin reorganization during Legionella pneumophila infection.

Nucleosome positioning on large tandem DNA repeats of the '601' sequence engineered in Saccharomyces cerevisiae

The paper tests if the 601 DNA sequence can position nucleosomes in vivo in yeast, finding that it does not reliably do so in a tandem repeat array context.

Cohesin regulates homology search during recombinational DNA repair

This study shows cohesin promotes cis dsDNA over-sampling during homology search in yeast by blocking cohesin progression and enabling loop expansion-coupled scanning.

FACT mediates cohesin function on chromatin

This study shows that FACT is required for cohesin stability on chromatin and the formation of cohesin-dependent TAD-like structures, but not sister chromatid cohesion.

A major role for Eco1 in regulating cohesin-mediated mitotic chromosome folding

The paper identifies Eco1's role in negatively regulating cohesin translocase activity during yeast mitosis, affecting DNA loop extrusion and chromosome folding.

Redesigning chromosomes for optimized Hi-C assay provides insights on loop formation and homologs pairing during meiosis

The paper redesigns a genomic region for improved Hi-C analysis, revealing insights into homolog pairing and loop formation during meiosis.

Choreography of budding yeast chromosomes during the cell cycle

The paper uses Hi-C to analyze chromosome structure dynamics in budding yeast during the cell cycle, revealing SMC-dependent structural transitions and mitotic reorganization.