Sunil Sudarshan

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

This study identifies DKC1-mediated pseudouridylation of rRNA as essential for sustaining IRES-dependent translation and ATF4-driven metabolic adaptation in neuroblastoma.

This study shows the mevalonate pathway supports amino acid synthesis by promoting mitochondrial NAD regeneration through ubiquinone-dependent electron transport, and statin inhibition disrupts this process.

This study shows that L2hgdh in Drosophila renal tubules prevents L-2HG accumulation, supports mitochondrial metabolism, and enables hypoxia tolerance.

The paper introduces NanoPsiPy, a pipeline for detecting pseudouridylation sites using nanopore sequencing, and shows PUS7-dependent pseudouridylation affects m6A and m5C levels.

The paper investigates L-2-hydroxyglutarate (L-2HG) accumulation in 18 insect species, finding high levels in Dipterans and suggesting a potential role in their development and pest control.