This paper introduces Trias, a generative language model that designs mRNAs with high protein output by learning codon usage rules from natural sequences.

bioRxiv · May 13, 2025 · PreprintGenomics

Circadian rhythms mediate malaria transmission potential

Inês Bento, Brianna A. Parrington, Rushlenne Pascual, Alexander S. Goldberg, Eileen Wang, Hani Liu, Helene Borrmann, Mira Zelle, Nicholas Coburn, Joseph S. Takahashi, Joshua Eric Elias, Maria M. Mota, Filipa Rijo‐Ferreira

The paper shows that mosquito salivary gland and sporozoite gene expression cycles with the day-night rhythm, affecting malaria transmission.

Nature Microbiology · Mar 31, 2025Peer-reviewedMicrobiology

Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression

Xiaodong Alan Zhuang, Giulia Gallo, Parul Sharma, Jiyeon Ha, Andrea Magri, Helene Borrmann, James Michael Harris, Senko Tsukuda, Eleanor G. Bentley, Adam Kirby, Simon De Neck, Hongbing Yang, Peter Balfe, Peter A. C. Wing, David A. Matthews, , Jane A. McKeating

This study shows that hypoxia inducible factors (HIFs) suppress RSV infection by reducing nucleolin expression and inhibiting viral replication and inflammation.

iScience · Dec 18, 2023Peer-reviewedMolecular Biology