This study identifies XRN1 as a key regulator of HDV infection, showing it controls viral replication through dsRNA homeostasis and innate immune activation.

bioRxiv · Nov 2, 2026 · PreprintMolecular Biology

Time-resolved proteomic analysis of hepatitis B virus infection

Mohammed Akbor Akbor, Medhi Boutasbih, Alexander Koenig, Eunji Jo, Iolanda Vendrell, Svenja Hester, Senko Tsukuda, Monica M. Olcina, Marc Peter Windisch, Jane A. McKeating, Benedikt Mathias Kessler, Andreas Damianou

This study uses time-resolved proteomics to analyze host protein changes during early HBV infection, revealing coordinated proteome alterations and specific complement pathway dynamics.

bioRxiv · Oct 16, 2026 · PreprintMicrobiology

Hypoxia inducible factors regulate Pneumovirus replication by enhancing innate immune sensing

Jiyeon Ha, Parul Sharma, Shibang Ta, Senko Tsukuda, James M. Harris, Rebekah Penrice-Randal, Eleanor G. Bentley, Adam Kirby, Daniele F. Mega, David A. Matthews, Peter Balfe, Jan Rehwinkel, Anja Kipar, James P. Stewart, Jane A. McKeating, Peter A. C. Wing

This study shows that HIF activation limits pneumovirus replication by enhancing innate immune sensing and reducing viral RNA methylation.

Proceedings of the National Academy of Sciences · Apr 7, 2026Peer-reviewedMicrobiology

PreS1-decorated recombinant adenovirus encoding HBV antigens generates neutralizing humoral and cellular immunity

Rebecca A Russell, James B. Lok, James Michael Harris, Senko Tsukuda, Louisa M. Rose, Bethany G. Charlton, Ivana Carey, Kosh Agarwal, Peter A. C. Wing, Sumi Biswas, Jane A. McKeating, Matthew D. J. Dicks

This study develops a vaccine using PreS1-decorated adenovirus that induces neutralizing antibodies and T-cell responses against HBV and HDV.

bioRxiv · Jan 30, 2026 · PreprintBioengineering

Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome

Haiqi Xu, Linzhen Kong, Jingfei Cheng, Khatoun Al Moussawi, Xiufei Chen, Aleema Iqbal, Peter A. C. Wing, James M. Harris, Senko Tsukuda, Azman Embarc Buh, Guifeng Wei, Alfredo Castelló, Skirmantas Kriaučionis, Jane A. McKeating, Xin Lü, Chun‐Xiao Song

This paper introduces BACS, a method for single-base resolution pseudouridine quantification, and identifies {Psi} sites in human RNA and viral transcripts.

Nature Methods · Sep 30, 2024Peer-reviewedMolecular Biology

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.

Senko Tsukuda, James Michael Harris, Andrea Magrì, Peter Balfe, Peter AC Wing, Aleem Siddiqui, Jane A. McKeating

This study shows that ALKBH5, an N6-methyladenosine demethylase, regulates HBV and host gene expression under hypoxic conditions by affecting viral transcript stability.

PLoS Pathogens · Jan 16, 2024Peer-reviewedMolecular Biology

Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression

Xiaodong Alan Zhuang, Giulia Gallo, Parul Sharma, Jiyeon Ha, Andrea Magri, Helene Borrmann, James Michael Harris, Senko Tsukuda, Eleanor G. Bentley, Adam Kirby, Simon De Neck, Hongbing Yang, Peter Balfe, Peter A. C. Wing, David A. Matthews, , Jane A. McKeating

This study shows that hypoxia inducible factors (HIFs) suppress RSV infection by reducing nucleolin expression and inhibiting viral replication and inflammation.

iScience · Dec 18, 2023Peer-reviewedMolecular Biology

Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection

Lewis Taylor, Felix Von Lendenfeld, Anna Ashton, Harshmeena Sanghani, Simona Di Pretoro, Laura E J Usselmann, Maria Veretennikova, Robert Dallmann, Jane A. McKeating, Sridhar R. Vasudevan, Aarti Jagannath

This study shows that sleep deprivation alters the mouse lung transcriptome, suppressing immune systems and activating SARS-CoV-2 replication genes, increasing viral infection risk.

iScience · Dec 24, 2022Peer-reviewedNeuroscience