Author

Peter Balfe

University of OxfordORCID 0000-0002-6246-0876Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jane A. McKeatingiD· 4 shared Senko TsukudaiD· 4 shared James Michael HarrisiD· 3 shared Adam KirbyiD· 2 shared Anja KipariD· 2 shared David A. MatthewsiD· 2 shared Eleanor G. BentleyiD· 2 shared James P. StewartiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Jane A. McKeatingORCID

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4 papers

Recent·Most cited

XRN1-dependent RNA homeostasis regulates hepatitis D virus

Senko Tsukuda, Medhi Boutasbih, Peter A.C. Wing, Aleksandr Fedorov, Xiaxuan Zhu, Jan Rehwinkel, Peter Balfe, Jane A. McKeating

This study identifies XRN1 as a key regulator of HDV infection, showing it controls viral replication through dsRNA homeostasis and innate immune activation.

bioRxiv · Nov 2, 2026 · PreprintMolecular Biology

Hypoxia inducible factors regulate Pneumovirus replication by enhancing innate immune sensing

Jiyeon Ha, Parul Sharma, Shibang Ta, Senko Tsukuda, James M. Harris, Rebekah Penrice-Randal, Eleanor G. Bentley, Adam Kirby, Daniele F. Mega, David A. Matthews, Peter Balfe, Jan Rehwinkel, Anja Kipar, James P. Stewart, Jane A. McKeating, Peter A. C. Wing

This study shows that HIF activation limits pneumovirus replication by enhancing innate immune sensing and reducing viral RNA methylation.

Proceedings of the National Academy of Sciences · Apr 7, 2026Peer-reviewedMicrobiology

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.

Senko Tsukuda, James Michael Harris, Andrea Magrì, Peter Balfe, Peter AC Wing, Aleem Siddiqui, Jane A. McKeating

This study shows that ALKBH5, an N6-methyladenosine demethylase, regulates HBV and host gene expression under hypoxic conditions by affecting viral transcript stability.

PLoS Pathogens · Jan 16, 2024Peer-reviewedMolecular Biology

Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression

Xiaodong Alan Zhuang, Giulia Gallo, Parul Sharma, Jiyeon Ha, Andrea Magri, Helene Borrmann, James Michael Harris, Senko Tsukuda, Eleanor G. Bentley, Adam Kirby, Simon De Neck, Hongbing Yang, Peter Balfe, Peter A. C. Wing, David A. Matthews, , Jane A. McKeating

This study shows that hypoxia inducible factors (HIFs) suppress RSV infection by reducing nucleolin expression and inhibiting viral replication and inflammation.

iScience · Dec 18, 2023Peer-reviewedMolecular Biology