Helen Sakharova

This study identifies Gim3 as a critical regulator of meiotic chromosome segregation in budding yeast, revealing its role in spindle sensitivity to tubulin levels and meiotic cellular remodeling.

The paper uses protein language models to uncover evolutionary constraints on synonymous codon choice in yeast by combining sequence analysis with experimental validation.

This paper introduces Trias, a generative language model that designs mRNAs with high protein output by learning codon usage rules from natural sequences.