Julia Sanchez‐Garrido

PgaR is a positive regulator of the pgaABCD biosynthetic operon in Klebsiella pneumoniae

This paper identifies PgaR as a positive regulator of the pgaABCD operon in Klebsiella pneumoniae, showing that genetic variation in this region leads to loss or hyper-production of PNAG, with distinct fitness consequences.

Citrobacter rodentium infection reveals preserved intestinal resilience in aged intestine

This study shows that aged mice have increased susceptibility to Citrobacter rodentium infection but retain distinct molecular and inflammatory responses depending on the pathogen's virulence.

TraN variants mediate conjugation species specificity of IncA/C, IncH and Acinetobacter baumannii plasmids

H pilin cyclisation and pilus biogenesis are promiscuous but electrostatic perturbations impair conjugation efficiency

The paper shows that pilin cyclisation and pilus formation are robust to amino acid substitutions, but electrostatic changes impair conjugation efficiency.

Stable coexistence of Citrobacter rodentium with a lytic bacteriophage during in vivo murine infection

This paper investigates phage-pathogen interactions in vivo using Citrobacter rodentium and a novel lytic phage, showing stable coexistence without reducing bacterial burden or inflammation.

citrOgen: a synthesis-free polysaccharide and protein antigen-presentation to antibody-induction platform

The paper introduces a platform using Citrobacter rodentium to generate antibodies against bacterial polysaccharides and proteins without requiring purified or synthetic antigens.

Evaluation of Klebsiella pneumoniae antigen MrkA reveals expression-limited therapeutic potential

The paper evaluates MrkA expression variability in Klebsiella pneumoniae and shows that anti-MrkA mAb efficacy depends on antigen abundance.

Genomic and molecular characterisation of a Klebsiella pneumoniae clinical isolate resistant to meropenem-vaborbactam, imipenem-relebactam, and ceftazidime-avibactam

This paper characterizes a Klebsiella pneumoniae isolate resistant to three beta-lactam/beta-lactamase inhibitor combinations, identifying genetic factors contributing to its resistance.

The accessory type III secretion system effectors shape intestinal inflammatory infection outcomes

The study identifies 12 accessory T3SS effectors in Citrobacter rodentium that influence infection outcomes without affecting virulence.

The exopolysaccharide Poly-N-Acetyl-Glucosamine (PNAG) coats Klebsiella pneumoniae in vivo

This paper shows that Klebsiella pneumoniae produces extracellular PNAG in vitro but switches to cell-associated PNAG during lung infection, highlighting its potential as a vaccine antigen.