Gad M. Frankel

This paper identifies PgaR as a positive regulator of the pgaABCD operon in Klebsiella pneumoniae, showing that genetic variation in this region leads to loss or hyper-production of PNAG, with distinct fitness consequences.

This study identifies two IncHI1 megaplasmids in Klebsiella species carrying blaIMP-1, showing transposable element-mediated mobilisation and conjugative transfer.

This study shows that aged mice have increased susceptibility to Citrobacter rodentium infection but retain distinct molecular and inflammatory responses depending on the pathogen's virulence.

This study identifies how personalized gut microbiotas influence the competitiveness of antibiotic-resistant pathogens through carbohydrate competition and specific genetic mutations.

This study shows hypervirulent Klebsiella pneumoniae uses its capsule to prevent neutrophil activation, allowing bacterial survival despite immune presence.

The paper shows that pilin cyclisation and pilus formation are robust to amino acid substitutions, but electrostatic changes impair conjugation efficiency.

This paper investigates phage-pathogen interactions in vivo using Citrobacter rodentium and a novel lytic phage, showing stable coexistence without reducing bacterial burden or inflammation.

The paper introduces a platform using Citrobacter rodentium to generate antibodies against bacterial polysaccharides and proteins without requiring purified or synthetic antigens.

This study shows GBP1 is recruited to actin-rich pedestals formed by extracellular pathogens, promoting pyroptosis and IL-18 release, independent of LPS.

This study shows that intestinal immunological challenges shape the polarization of dural CD4 T cells, which provide protective memory against pathogens.

The paper evaluates MrkA expression variability in Klebsiella pneumoniae and shows that anti-MrkA mAb efficacy depends on antigen abundance.

This paper characterizes a Klebsiella pneumoniae isolate resistant to three beta-lactam/beta-lactamase inhibitor combinations, identifying genetic factors contributing to its resistance.

This study shows that colonic ILC2s are activated during Citrobacter rodentium infection, secreting type 2 cytokines, and that IL-18 drives their activation.

The paper reports the cryo-EM structure of the RP4 conjugation pilus, revealing it is functional without phospholipid modification, challenging previous assumptions about pilus biogenesis.

This study shows that resolving an enteric infection with Citrobacter rodentium protects mice from chemically-induced colitis via IL-17A-dependent immune reprogramming.

The paper reports the cryo-EM structure of the H-pilus, revealing its cyclic pilin subunit and explaining its role in conjugation.

The study identifies 12 accessory T3SS effectors in Citrobacter rodentium that influence infection outcomes without affecting virulence.

This study shows that the hypervirulent Klebsiella pneumoniae capsule masks O-antigen, preventing neutrophil recognition and killing, while O-antigen can also trigger neutrophil degranulation and NET formation.

The paper determines the cryo-EM structure of TraT proteins from plasmids and reveals their evolutionary history, showing independent acquisition by different plasmid backbones.

This paper shows that Klebsiella pneumoniae produces extracellular PNAG in vitro but switches to cell-associated PNAG during lung infection, highlighting its potential as a vaccine antigen.

The paper identifies over 16,000 secreted proteins in Legionella species, revealing their ability to acquire eukaryotic-like genes for intracellular replication in human cells.