Salina Quack

A multimodal, correlative magnetic tweezers-TIRF platform for high-throughput single-molecule interrogations

This paper introduces a multimodal platform combining magnetic tweezers and TIRF for high-throughput single-molecule analysis, enabling real-time, parallel measurements of force, torque, fluorescence, and temperature.

Accurate single-bead force calibration in high-throughput magnetic tweezers reveals the mechanism of directional transcription termination by MTERF1

This paper develops an in-situ force calibration method for magnetic tweezers and uses it to reveal how MTERF1 causes directional transcription termination through DNA unwinding and a kinetic barrier.

Single-molecule magnetic tweezers reveals that TAV2b-derived peptides underwind and stabilize double-stranded RNA

The paper uses single-molecule magnetic tweezers to study how TAV2b-derived peptides affect dsRNA structure and stability, finding they underwind and stabilize the duplex.

MDA5 generates compact ribonucleoprotein complexes via ATP-dependent single-stranded RNA loop extrusion

This study shows MDA5 compacts dsRNA via ATP-dependent loop extrusion, stabilizing the structure through CARD domain oligomerization.

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.

This study models the structural changes in the Chd1 protein when bound to nucleosomes, revealing how ATP binding alters its conformation and DNA interactions.