Author

Tiantian Shang

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Organism:human· 1 Assay:scRNA-seq· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Taekjip HaiD· 2 shared Arman Ahmed· 1 shared Christopher M. JansoniD· 1 shared Doug BarrickiD· 1 shared Douglas Yeu MahiD· 1 shared Fahad RashidiD· 1 shared James M. BergeriD· 1 shared Jimin KangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

Taekjip HaORCID

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2 papers

Recent·Most cited

Rapid functional classification of cardiac genetic variants directly informs precision cardiology

Xiao-Ting Wang, Po-Ta Chen, Joshua Mayourian, Leona M. Ripple, Yashasvi Tharani, Tiantian Shang, Nikoleta Pavlaki, Kevin Shani, Yongjun Jang, Christopher M. Janson, Douglas Yeu Mah, Kevin Kit Parker, William T. Pu, Taekjip Ha, Vassilios J. Bezzerides

This paper introduces REVi-SCOPE, a platform that rapidly characterizes cardiac variants' functional impact, enabling precision cardiology by analyzing VUSs in 10 days.

bioRxiv · Apr 19, 2026 · PreprintBioengineering

Superhelicase-driven isothermal amplification of repetitive and low-complexity DNA

Fahad Rashid, Jimin Kang, Tiantian Shang, Peter J. Murray, Xiaotian Bi, Raquel Merino‐Urteaga, Momcilo Gavrilov, Wonyoung Jo, Arman Ahmed, Qianyun Yan, Tural Aksel, Doug Barrick, James M. Berger, Taekjip Ha

This study demonstrates that SHARP, a helicase-driven isothermal amplification method, effectively amplifies repetitive and compositionally extreme DNA sequences that are challenging for conventional PCR.

bioRxiv · Nov 27, 2024 · PreprintBiophysics