Stephen B. Shears

This study identifies the host soluble inositol phosphate pathway as critical for coronavirus replication and demonstrates a multi-target inhibitor that effectively suppresses viral replication in cells and mice.

The paper reports 14 co-crystal structures of human IPMK with inhibitors and identifies structural features contributing to inhibitor potency and selectivity.

This study reveals how KIDINS220 and InsP8 regulate XPR1's phosphate export through structural mechanisms and evolutionary insights.