Author

João Paulo De Aquino

Yale UniversityORCID 0000-0001-7357-8215Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Abigail L. YuiD· 1 shared Alex C. KwaniD· 1 shared Alfred P. KayeiD· 1 shared Christopher PittengeriD· 1 shared Frank S. MennitiiD· 1 shared Gabriele FlorisiD· 1 shared Jocelyne A. Rondeau· 1 shared John H. Krystal· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Abigail L. YuORCID

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1 paper

Recent·Most cited

Enhancing cGMP signaling with psilocybin reduces head twitch and restructures the synaptic proteome while maintaining antidepressant response

Gabriele Floris, Sarah J. Jefferson, Jocelyne A. Rondeau, Abigail L. Yu, Frank S. Menniti, Alex C. Kwan, João Paulo De Aquino, John H. Krystal, Christopher Pittenger, Alfred P. Kaye

This study combines psilocybin with a PDE9 inhibitor to reduce head-twitch response and alter synaptic proteome while preserving antidepressant effects.

bioRxiv · Apr 16, 2026 · PreprintNeuroscience