Fleur Bourdelais

This study identifies CYCLON as a nucleolar protein that regulates cancer cell fitness by controlling ribosome biogenesis and nucleolar structure across multiple tumor types.

This study identifies ribosome biogenesis as a therapeutic vulnerability in TNBC, showing that inhibiting rRNA maturation via Fibrillarin or RNA Pol I reduces tumor growth without significant cell death.

This study identifies RSL24D1 as a key regulator of ribosome biogenesis and pluripotency in mouse embryonic stem cells, showing its role in maintaining self-renewal and suppressing differentiation.