Frédéric Catez

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

This study identifies eL21 as an externalized ribosomal protein in triple negative breast cancer cells and shows anti-eL21 antibodies induce anti-proliferative effects.

This study identifies ribosome biogenesis as a therapeutic vulnerability in TNBC, showing that inhibiting rRNA maturation via Fibrillarin or RNA Pol I reduces tumor growth without significant cell death.

This study investigates ribosome biogenesis as a therapeutic target in neuroblastoma, showing that inhibiting RNA polymerase I reduces cell proliferation and induces apoptosis.

The paper shows 5-FU induces translational reprogramming in colorectal cancer cells, enhancing drug tolerance through pro-tumoral gene expression and IL-8 overexpression.

This study identifies RSL24D1 as a key regulator of ribosome biogenesis and pluripotency in mouse embryonic stem cells, showing its role in maintaining self-renewal and suppressing differentiation.

This paper shows DHX30 coordinates cytoplasmic and mitochondrial translation, affecting cancer cell survival and prognosis through a 15-gene signature.