Daniel J. Brooks

This study shows that social isolation reduces bone parameters in male mice but not females, with effects appearing rapidly in males and some changes in females after short-term isolation.

This paper deletes Dock7 exons 3-4 in mice, resulting in reduced trabecular bone volume and altered osteoblast function.

This study shows intermittent parathyroid hormone drives osteogenesis from Ebf3-expressing progenitors via both intrinsic and extrinsic mechanisms in mice and humans.

This study shows that deleting SIK2/SIK3 in alveolar bone reduces bone formation and mass by impairing osteoblast maturation, unlike in long bones where it increases bone formation and mass.

This study identifies Sp7 and its target gene osteocrin as critical for osteocyte dendrite formation and shows their role in human skeletal diseases.

The paper uses Diversity Outbred mice to analyze bone traits and identify novel genes associated with bone strength, informing human GWAS findings.