The paper identifies DNA sequence cis determinants that drive heterochromatin nucleation and maintenance in Plasmodium falciparum using genetic screening and chromatin immunoprecipitation.

PLoS Pathogens · Jun 2, 2025Peer-reviewedMolecular Biology

Targeted DamID detects cell-type specific histone modifications in vivo

Jelle van den Ameele, Manuel Trauner, Eva Hörmanseder, Alex P. A. Donovan, Oriol Llorà-Batlle, Seth W. Cheetham, Robert Krautz, Rebecca Yakob, John Bertrand Gurdon, Andrea H. Brand

The paper introduces Targeted DamID to detect cell-type specific histone modifications in vivo across different model organisms.

bioRxiv · Apr 11, 2024 · PreprintMolecular Biology

10x Genomics Gene Expression Flex is a powerful tool for single-cell transcriptomics of xenograft models

Oriol Llorà-Batlle, Anca M. Farcas, Doreth Fransen, Nicolas Floc’h, Sara Talbot, Alix Schwiening, Laura Bojko, John Calver, Nataša Josipović, Kanstantsin Lashuk, Julia B. Schüler, Andrei Prodan, Dylan Mooijman, Ultan McDermott

The paper demonstrates that the 10x Genomics Gene Expression Flex protocol can profile mixed human and mouse cells in xenografts by using combined probe sets and a pipeline to remove cross-reactive signals.

bioRxiv · Jan 25, 2024 · PreprintGenomics

An organoid CRISPRi screen revealed that SOX9 primes human fetal lung tip progenitors to receive WNT and RTK signals

Dawei Sun, Oriol Llorà-Batlle, Jelle van den Ameele, John Christopher Thomas, Peng He, Kyungtae Lim, Walfred W. C. Tang, Chu‐Fan Xu, Kerstin B. Meyer, Sarah Amalia Teichmann, John C. Marioni, Stephen P. Jackson, Andrea H. Brand, Emma L. Rawlins

The paper uses a CRISPRi screen in human fetal lung organoids to identify SOX9 as a key regulator of progenitor self-renewal, showing it primes cells to receive WNT and RTK signals.

bioRxiv · Jan 27, 2022 · PreprintDevelopmental Biology