Yiran Zheng

The paper shows bacterial invasion and neutrophil immunosuppression drive adenoma progression in a porcine FAP model using single-cell RNA sequencing and spatial transcriptomics.

This study identifies Topoisomerase I as a conserved regulator of satellite DNA transcription across species, showing its role in centromere function and DNA damage response.

The paper estimates the prevalence of putatively pathogenic leptin variants in the gnomAD database, finding low frequencies with higher risk in South Asian populations.