Author

Pamela Fischer‐Posovszky

University Hospital UlmORCID 0000-0003-3402-9840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Cell Biology· 1 Genetics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Daniel TewsiD· 3 shared Martin WabitschiD· 3 shared Alexander BarteltiD· 2 shared Jan MünchiD· 2 shared Julia ZinngrebeiD· 2 shared Kirsi A. VirtaneniD· 2 shared Manuel Gil‐LozanoiD· 2 shared Marcel ScheideleriD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMolecular Biology

Daniel TewsORCID

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Author profile →

6 papers

Recent·Most cited

GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

Dan Albers, Sofya Novikova, Julio Vieyto‐Nuñez, Yasser Almeida‐Hernández, Chiara Pastorio, Florian Klassen, Dana Weiss, Pascal von Maltitz, Janeni Jaikishan, Moumita Datta, Hassan Jumaa, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer, Manish Kumar, Palash Chandra Maity, , Mirja Harms

This study shows GPR15LG binds CXCR4, enhancing CXCL12-induced signaling and promoting cell migration in immune and cancer cells.

Cell Communication and Signaling · May 20, 2025Peer-reviewedCell Biology

SEVI Fibrils are Induced by Bacterial Surface Molecules and Exert Antimicrobial Activity Against ESKAPE Pathogens

Verena Vogel, Lia‐Raluca Olari, Richard Bauer, Sandra Burczyk, Fiona Witz, Emely Walker, Nourice Jaber, Stefanie Mauerer, Ulrich Rupp, Ulrich Stifel, Julia Zinngrebe, Clarissa Read, Pamela Fischer‐Posovszky, Jan Münch, Barbara Spellerberg

This study shows SEVI fibrils have antibacterial activity against urogenital pathogens and are induced by bacterial surface molecules.

bioRxiv · Jan 31, 2025 · PreprintMicrobiology

Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies

Lena Molitor, Melina Klostermann, Sabrina Bacher, Juliane Merl‐Pham, Nadine Spranger, Sandra Burczyk, Carolin Ketteler, Ejona Rusha, Daniel Tews, Anna Pertek, Marcel Proske, Anke Busch, Sarah Reschke, Regina Feederle, Stefanie M. Hauck, , Dierk Niessing

This study shows that PURA depletion affects posttranscriptional regulation and P-body formation, linking PURA Syndrome to neurodevelopmental disorders.

Nucleic Acids Research · Dec 13, 2022Peer-reviewedMolecular Biology

Prevalence Estimates of Putatively Pathogenic Leptin Variants in the gnomAD Database

Luisa Sophie Rajcsanyi, Yiran Zheng, Pamela Fischer‐Posovszky, Martin Wabitsch, Johannes Hebebrand, Anke Hinney

The paper estimates the prevalence of putatively pathogenic leptin variants in the gnomAD database, finding low frequencies with higher risk in South Asian populations.

PLoS ONE · Sep 19, 2022Peer-reviewedGenetics

The obesity-linked human lncRNA AATBC regulates adipocyte plasticity by stimulating mitochondrial dynamics and respiration

Maude Giroud, Stefan Kotschi, Yun Kwon, Ophélia Le Thuc, Anne Hoffmann, Manuel Gil‐Lozano, Michael Karbiener, Juan Carlos Higareda‐Almaraz, Sajjad Khani, Daniel Tews, Pamela Fischer‐Posovszky, Wenfei Sun, Hua Dong, Adhideb Ghosh, Christian Wolfrum, , Alexander Bartelt

This study identifies AATBC as a human-specific lncRNA that regulates adipocyte plasticity and mitochondrial function, linking it to metabolic health.

bioRxiv · Aug 9, 2021 · PreprintMolecular Biology

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signaling

Maude Giroud, Foivos‐Filippos Tsokanos, Giorgio Caratti, Stefan Kotschi, Sajjad Khani, Céline Jouffe, Elena Sophie Vogl, Martin Irmler, Christina Glantschnig, Manuel Gil‐Lozano, Daniela Hass, Asrar Ali Khan, Marcos Ríos García, Frits Mattijssen, Adriano Maida, , Stephan Herzig

This study identifies HAND2 as an obesity-linked adipogenic transcription factor regulated by glucocorticoids, showing its role in adipocyte differentiation and its correlation with BMI in humans.

Diabetologia · May 20, 2021Peer-reviewedMolecular Biology