Qin Wang

This study identifies a pathway involving Rtca, Rab10, and Itgb1 that regulates Piezo localization and function, promoting axon regeneration inhibition in Drosophila and mice.

The paper uses case-control data from over 400,000 women to classify BRCA1 and BRCA2 variants, finding high consistency with ClinVar annotations for 785 previously unclassified variants.

The paper uses whole-exome sequencing data to identify novel breast cancer susceptibility genes and assess the contribution of coding variants to breast cancer risk.

This study identifies the Piezo-Atr-Chek1-Cdc25 pathway as an inhibitory mechanism for axon regeneration, showing that disrupting it enhances regeneration in Drosophila and mammals.

The paper identifies pathogenic variants in SMARCA5 as a cause of a neurodevelopmental syndrome with mild facial dysmorphia and developmental delay.

The paper identifies ISWI as a chromatin remodeler required for adult sleep in Drosophila, with distinct developmental roles in sleep and other behaviors.

This study uses optogenetics to activate ERK and AKT signaling in Drosophila, enhancing axon regeneration and functional recovery in both PNS and CNS.