Takeshi Egawa

This study identifies high-avidity TCR signaling via NFAT as a key driver of NKG2A-positive CD8 T cell exhaustion in human tumors, with implications for immunotherapy.

This study shows that inflammaging in aged tissues drives the development of age-associated CD8+ T cells through adipose tissue niches.

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

TCR-BERT uses self-supervised transfer learning on unlabeled T-cell receptor sequences to learn representations that improve antigen-binding prediction, specificity clustering, and computational TCR sequence design.