The paper identifies complement deactivation as an immunometabolic checkpoint reduced by calorie restriction, which lowers inflammaging in humans and mice.

Nature Aging · Apr 13, 2026Peer-reviewedPhysiology

Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.

Aileen H. Lee, Lucie Orliaguet, Yun‐Hee Youm, Rae Maeda, Tamara Dlugos, Yuanjiu Lei, Daniel Coman, Irina Shchukina, Prabhakar Sairam Andhey, Steven R. Smith, Éric Ravussin, Krisztián Stadler, Bandy Chen, Maxim N. Artyomov, Fahmeed Hyder, , Vishwa Deep Dixit

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

Nature Metabolism · Jun 3, 2025Peer-reviewedPhysiology

Single Cell Transcriptomics Reveals Cell Type Specific Diversification in Human Heart Failure

Andrew L. Koenig, Irina Shchukina, Junedh Amrute, Prabhakar Sairam Andhey, Konstantin Zaitsev, Lulu Lai, Geetika Bajpai, Andrea L. Bredemeyer, Gabriella Smith, Cameran Jones, Emily Terrebonne, Stacey Rentschler, Maxim N. Artyomov, Kory J. Lavine

This study uses single cell transcriptomics to analyze heart failure in humans, identifying cell type-specific transcriptional changes and disease-associated states.

Nature Cardiovascular Research · Mar 16, 2022Peer-reviewedGenomics

Epigenetic aging of classical monocytes from healthy individuals

Irina Shchukina, Juhi Bagaitkar, Oleg Shpynov, Ekaterina Loginicheva, Sofia I. Porter, Denis A. Mogilenko, Erica Wolin, Patrick L. Collins, German M. Demidov, Mykyta Artomov, Konstantin Zaitsev, Sviatoslav Sidorov, Christina D. Camell, Monika Bambousková, Laura Arthur, , Maxim N. Artyomov

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.

bioRxiv · May 10, 2020 · PreprintSystems Biology