Yuliya Gordiyenko

Mechanism of translation initiation on endogenous eukaryotic circular RNAs

This study investigates translation initiation mechanisms on endogenous eukaryotic circular RNAs, showing that initiation depends on UTRs and specific initiation factors.

Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation

This study identifies the structural basis of RECQL5-induced RNA polymerase II transcription braking and reveals its coordination with the TCR complex for reactivation.

Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

The paper reports the cryo-EM structure of a transcribing Pol II-U1 snRNP complex with DSIF and SPT6, showing how phosphorylated Pol II and SPT6 interact with U1 snRNP to facilitate spliceosome assembly and transcription processivity.

Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in 40S small ribosomal subunit

This study determines the structure of Pdcd4 bound to the 40S ribosomal subunit, revealing its binding site and mechanism in translational control.

The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A

The paper describes the structure of a human 48S initiation complex, revealing a second eIF4A helicase at the mRNA entry site that unwinds secondary structure downstream of the scanning complex.

eIF3b and eIF3i relocate together to the ribosomal subunit interface during translation initiation and modulate start codon selection

The paper shows eIF3b and eIF3i move to the ribosomal subunit interface during translation initiation and affect start codon selection in yeast.