John Stuart O'Neill

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

The paper introduces iClima, a ratiometric genetically encoded sensor for imaging GABAergic chloride currents, showing it can detect Cl- transients in vitro and in vivo with improved photostability and pH independence.

The paper shows that glucocorticoid receptor signaling resets circadian rhythms through post-transcriptional mechanisms, not transcriptional activation.

The paper shows that circadian rhythms in intracellular potassium levels regulate the cell cycle in algae and mammalian cells.

This study shows that microbial exposure can reset circadian timing in mammals, plants, and algae through a mechanism independent of canonical immune pathways.

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

The paper shows yeast cells use temporal metabolic oscillations to coordinate protein synthesis with energy availability, storing resources and releasing them in bursts to maintain homeostasis.

The paper investigates how glucose availability affects synchronous activity in excitatory neural networks and finds that glucose is essential for sustaining high-frequency bursting, while lactate and pyruvate cannot substitute.