Author

Wenjuan Ye

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Mark J. HendersoniD· 2 shared Abigail M Keith· 1 shared Anton M. SimeonoviD· 1 shared CRIS M. BROWN· 1 shared Fumihiko UranoiD· 1 shared Giuseppe DeganuttiiD· 1 shared Jeffrey R. MillmaniD· 1 shared Joseph Ekstein· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Mark J. HendersonORCID

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2 papers

Recent·Most cited

Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay

Wenqin Xu, Abigail M Keith, Wenjuan Ye, Xin Yang Hu, Noel T Southall, Juan Marugán, Marc Ferrer, Mark J. Henderson, Patrick Michael Sexton, Giuseppe Deganutti, Lee E. Eiden

The paper designs peptide-based PAC1 antagonists using molecular dynamics simulations and a cell-based assay, finding that some proposed small molecule antagonists lack activity while confirming the efficacy of PACAP(6-38) and M65.

Biochemical Pharmacology · Sep 3, 2025Peer-reviewedPharmacology & Toxicology

Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome

Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, CRIS M. BROWN, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein, Joshua N. Cohen, Justin B. Klee, Kent L. Leslie, Anton M. Simeonov, Mark J. Henderson, , Fumihiko Urano

This study uses a patient-derived stem cell model to show that a specific WFS1 variant causes mild Wolfram syndrome, which can be treated with chemical chaperones.

bioRxiv · Nov 7, 2021 · PreprintGenetics