Yingchi Zhang

This study develops a three-step method to generate high-yield CAR NK cells from umbilical cord blood CD34+ HSPCs, reducing CAR engineering costs and enabling therapeutic applications.

The paper identifies high-risk factors and actionable targets in T-ALL through integrated genomic and transcriptomic analyses of 165 patients, finding RAS pathway and PTEN mutations as poor survival factors and potential therapeutic targets.

The paper constructs a single-cell atlas of hematopoiesis and leukemogenesis, identifies leukemia subpopulations, and develops a composite index to predict clinical outcomes.

This study shows that knocking out myosin IIA/B in retinal ganglion cells promotes optic nerve regeneration, with synergistic effects when combined with Lin28 overexpression.