Author

Lesley R. Golden

University of KentuckyORCID 0000-0001-8922-8850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Josh M. MorgantiiD· 3 shared Lance A. JohnsoniD· 3 shared Adeline E. WalshiD· 2 shared Cathryn T SmithiD· 2 shared Danielle S. Goulding· 2 shared Elizabeth J. Allenger· 2 shared Gabriela HernandeziD· 2 shared Holden C. WilliamsiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Josh M. MorgantiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 29, 2026

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events

Akhil V. Pallerla, Chloe C. Lucido, Kai Saito…·Lance A. Johnson

This study investigates how anti-amyloid immunotherapy affects APOE4 carriers, showing increased glial reactivity, perivascular immune activation, and ARIA-like events.

DOI 10.64898/2026.06.26.734793

mousespatial transcriptomics

𝕏 PostBluesky

NeuroscienceCell ReportsPeer-reviewedMar 1, 2023

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden…·Lance A. Johnson

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

203 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceMolecular NeurodegenerationPeer-reviewedSep 6, 2021

APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney…·Lance A. Johnson

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.

89 citationstop 1%

mousehuman

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