Author

Tom Snelling

Imperial College LondonORCID 0000-0001-7577-8798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetics· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell-cell communication· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Lesley HoylesiD· 2 shared Robert Charles GleniD· 2 shared Simon McArthuriD· 2 shared Simon Richard CardingiD· 2 shared Alban C. ZiegleriD· 1 shared Ana L. CarvalhoiD· 1 shared Antoinette PerlatiD· 1 shared David VauzouriD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSystems Biology

Lesley HoylesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 13, 2024

Discovery and functional analysis of a novel ALPK1 variant causing ROSAH syndrome

Tom Snelling, L. Olory-Garnotel, Isabelle Jéru…·Alban C. Ziegler

The paper identifies a new ALPK1 variant causing ROSAH syndrome and shows it has altered activation by different metabolites, explaining autoinflammatory episodes.

2 citations

humanexperimental assay

𝕏 PostBluesky

Systems BiologyMicrobiomePeer-reviewedNov 26, 2021

Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodríguez‐Ramiro…·Simon McArthur

This study shows that TMAO enhances BBB integrity and protects against inflammation, while TMA impairs BBB function and cognitive resilience in mice.

221 citationstop 1%

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceMicrobiomePeer-reviewedMar 21, 2018

Microbiome-host systems interactions: Protective effects of propionate upon the blood-brain barrier

Lesley Hoyles, Tom Snelling, Umm‐Kulthum Ismail Umlai…·Simon McArthur

The paper investigates how propionate, a gut microbial metabolite, interacts with the blood-brain barrier through CD14-dependent and NRF2 signaling pathways, suggesting a new mechanism in the gut-brain axis.

592 citationstop 1%

humanmetagenomics

𝕏 PostBluesky