Robert Charles Glen

This study identifies trimethylamine (TMA) as a microbial compound that inhibits IRAK4, reducing inflammation and improving metabolic outcomes in high-fat diet conditions.

This study shows p-cresol sulfate impairs the blood-brain barrier via EGFR activation and demonstrates EGFR blockade prevents this damage in vitro.

This study shows that TMAO enhances BBB integrity and protects against inflammation, while TMA impairs BBB function and cognitive resilience in mice.

The paper estimates permutation-based metabolome-wide significance thresholds using parametric approximations and permutation procedures to control type I error rates in metabolome-wide association studies.

This study investigates lipid composition changes in white adipose tissue during obesity, showing distinct effects of lipid storage versus membrane remodeling on cellular function.

The paper introduces a method using ion co-localization features to classify tumors from MSI data, addressing batch effects and generating hypotheses about sample classes.

PhenoMeNal provides a cloud-based platform for metabolomics data analysis, integrating tools and workflows to enable reproducible and scalable research.

The paper investigates how propionate, a gut microbial metabolite, interacts with the blood-brain barrier through CD14-dependent and NRF2 signaling pathways, suggesting a new mechanism in the gut-brain axis.